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A nested polymerase chain reaction was used for the detection of Epstein- Barr virus DNA in 1 patient with encephalitis,and in 1 patient with myelitis.Epstein-Barr virus DNA was detected in cerebrospinal fluid samples obtained at the onset of neurological symptoms in both patients, and serological findings indicated ongoing Epstein-Barr virus infection.In the patient with encephalitis,herpes simplex virus type 1 DNA was transiently detected in the cerebrospinal fluid,while Epstein-Barr virus DNA was still present on day 44 after admittance.Single-photon emission computed tomography in this patient indicated a frontal bilateral hypoperfusion.The diagnostic value of polymerase chain reaction on cerebrospinal fluid and serum samples for Epstein-Barr virus infections of the central nervous system is emphasized. |
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